TABLE 1.

Summary of ΦM1 escape mutations and effects on reading frames

Phage	Date of isolation	Position and mutation relative to ΦM1 wta	Effect on forward reading frameb:
			F1	F2	F3
ΦM1-A	March 2007	15416, A to C	Y to S	T to P	No change
ΦM1-B	March 2007	15292, C to T	R to stop	No change	P to L
ΦM1-C	March 2007	15170, T to C	M to T	Stop to S	No change
ΦM1-D	March 2007	15410, T to C	M to T	W to R	No change
ΦM1-O	June 2009	15407, A to C	Q to P	No change	No change
ΦM1-V	May 2009	15415, T to G	Y to D	No change	V to G
ΦM1-W	May 2009	15398, A to T	D to V	M to L	Stop to C
ΦM1-X	May 2009	15288, AA to A	FS to stop after 9 aa (wild-type F1 continues phiM1-23)	FS causing Q to H and stop after 3 aa (wild-type F2 stops after 9 aa)	FS causing N to T and shift of ORF1 into ORF2 (wild-type F3 stops after 3 aa)
ΦM1-Y	May 2009	15397, G to A
ΦM1-Z	May 2009	15416, A to G (cf. ΦM1-A)

^aMutations are indicated as, e.g., Y to S.

^bFS, frameshift; aa, amino acid.