Table I.
Parameter | Pre-injury | Injury | Po-4 | Po-2 | Po | Po+2 | Po+4 |
---|---|---|---|---|---|---|---|
VD/VT | 0.35±0.11 | 0.68±0.10a | 0.60±0.07a,b | 0.52±0.11a,b | 0.44±0.08a,b | 0.61±0.08a | 0.64±0.10a |
PaCO2 (mmHg) | 34.80±6.73 | 43.81±8.02a | 47.73±10.33a | 49.05±12.47a | 49.19±11.82a | 47.71±12.28a | 47.62±12.89a |
SaO2 (%) | 99.86±0.05 | 88.40±11.25a | 96.79±1.52b | 98.58±0.48b | 98.75±2.55b | 97.78±0.96b | 96.34±2.50b |
Qs/Qt (%) | 1.88±1.14 | 21.06±15.62a | 7.50±4.14a,b | 5.01±1.53b | 2.77±2.53b | 6.68±2.86b | 9.55±5.85a,b |
P/F (mmHg) | 562±162 | 75±21a | 166±109a | 291±62a,b | 342±144a,b | 365±133a,b | 294±170a,b |
Cdyn (ml/cm H2O) | 38.17±6.97 | 15.17±5.37a | 17.83±3.81a | 18.00±4.97a | 20.67±5.58a,b | 19.33±4.44a,b | 17.50±3.34a |
P<0.05 vs. pre-injury
P<0.05 vs. injury. VD/VT, dead space volume/tidal volume (dead space fraction); PaCO2, alveolar partial pressure of carbon dioxide; SaO2, arterial oxygen saturation; Qs/Qt, intrapulmonary shunt fraction; P/F, alveolar partial pressure of oxygen/fraction of inspiration oxygen (oxygenation index); Cdyn, dynamic tidal respiratory compliance; Po, optimal positive end-expiratory pressure; -n, n cm Hg below Po; +n; n cm Hg above Po.