Table II.
Hemodynamics parameters of the acute respiratory distress syndrome swine model under different conditions (mean ± standard deviation).
| Parameter | Pre-injury | Injury | Po-4 | Po-2 | Po | Po+2 | Po+4 |
|---|---|---|---|---|---|---|---|
| CVP (mmHg) | 6.58±2.08 | 8.67±2.84a | 10.67±1.72a,b | 10.83±2.67a,b | 10.75±2.83a,b | 11.33±2.06a,b | 11.83±1.90a,b |
| CI (l/min/m2) | 4.84±2.08 | 3.36±1.62 | 3.80±1.86 | 3.75±2.00 | 3.75±2.09 | 2.96±1.46 | 2.67±1.22 |
| ITBI (ml/m2) | 694±219 | 664±201 | 561±240 | 690±229 | 611±202 | 597±201 | 590±130 |
| GEDI (ml/m2) | 555±175 | 532±161 | 449±192 | 552±183 | 488±162 | 478±160 | 472±104 |
| EVLWI (ml/kg) | 10.69±4.01 | 17.61±5.71a | 15.33±3.00a | 17.14±7.13a | 16.85±6.05a | 16.69±4.97a | 16.94±4.81a |
| SVRI (dyn.sec.cm−5.m2) | 1,430±590 | 2,113±1,012 | 2,469±948 | 2,541±1,366 | 2,179±1,439 | 2,152±1,532 | 1,970±1,237 |
a
P<0.05 vs. pre-injury
b
P<0.05 vs. injury. CVP, central venous pressure; CI, cardiac output index; ITBI, intra-thoracic blood volume index; GEDI, global end-diastolic volume index; ELWI, extravascular lung water index; SVRI, systemic vascular resistance index; Po, optimal positive end-expiratory pressure; -n, n cm Hg below Po; +n; n cm Hg above Po.