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. Author manuscript; available in PMC: 2017 Apr 3.
Published in final edited form as: J Biomol Screen. 2015 Apr 27;20(8):985–997. doi: 10.1177/1087057115583037

Figure 3.

Figure 3

M-RAM outperforms 2BHM.

(A) ROC curve comparing M-RAM’s (selective Lasso model for DNA damage initiation signaling) and 2BHM’s performance using leave-one-out cross validation. M-RAM provides superior sensitivity and specificity. AUC refers to area under the receiver operating characteristic (ROC) curve.

(B) Q-Q plot comparing the ranking of independent caffeine controls by M-RAM and 2BHM. M-RAM ranks the independent caffeine controls more accurately than 2BHM (closer to zero which indicates lower γH2AX and higher similarity to knock-down of genes belonging to DNA damage initiation signaling). Additionally, M-RAM ranks the controls more precisely (ranks provided by M-RAM have less than half the statistical spread than ranks provided by 2BHM). The p-value was computed using a Wilcoxon rank-sum test.

(C) Dot plot of Brd4 and selected PP2A subunit ranking as provided by M-RAM and 2BHM. As in (B), M-RAM ranks the genes more precisely and more accurately than 2BHM. Brd4 and PPP2R5A are displayed more than once because they were independently screened on multiple different plates.