Table 1.
Features selected by the selective Lasso models trained on DNA damage initiation and checkpoint signaling genes. Scaled weights represent feature weights that were normalized to sum to 100 for better readability.
| DNA damage initiation signaling | ||||
|---|---|---|---|---|
|
| ||||
| Readout | Time | Feature | Weight | Scaled weight |
|
| ||||
| H2AX | 1 | Maximum nucleic intensity | 0.039715 | 46 |
| Standard deviation of foci intensity | 0.022996 | 27 | ||
| Standard deviation of nuclei intensity | 0.012257 | 14 | ||
| Number of foci | 0.010534 | 12 | ||
|
| ||||
| pHH3 | 6 | Number of pHH3+ nuclei | 0.000333 | 1 |
| Checkpoint signaling | ||||
|---|---|---|---|---|
|
| ||||
| Readout | Time | Feature | Weight | Scaled weight |
|
| ||||
| H2AX | 0 | Number of foci | 0.007222 | 3 |
|
| ||||
| pHH3 | 0 | Standard deviation of pHH3+ nuclei | 0.047811 | 22 |
| Minimum nucleic intensity | 0.015302 | 7 | ||
| Maximum pHH3+ nucleic intensity | 0.014266 | 7 | ||
| Mean nucleic intensity | 0.004452 | 2 | ||
|
| ||||
| 1 | Number of pHH3+ nuclei | 0.057373 | 26 | |
| Integrated pHH3+ nucleic intensity | 0.042539 | 19 | ||
|
| ||||
| DNA | 24 | Integrated nucleic intensity | 0.006422 | 3 |
|
| ||||
| Tubulin | 6 | Minimum cellular intensity | 0.013966 | 6 |
|
| ||||
| 24 | Mean cellular intensity | 0.011349 | 5 | |