Table 2.
Best-ranked hits that resemble the knock-down phenotype of DNA damage initiation signaling genes (top) or the opposite phenotype (bottom).
| Top ten hits
| |||
|---|---|---|---|
| Gene symbol | Gene name | M-RAM rank | 2BHM rank |
|
| |||
| H2AFX | Histone H2A.X | 1 | 120 |
| ATM | Ataxia telangiectasia mutated | 2, 5 | 203, 1232 |
| PRKACG | cAMP-dependent protein kinase catalytic subunit γ | 3 | 537 |
| TEX14 | Testis expressed 14 | 4 | 2338 |
| BRCA2 | Breast cancer 2 | 6 | 8 |
| PRKAR1A | cAMP-dependent protein kinase type I-α regulatory subunit | 7 | 442 |
| EXO1 | Exonuclease 1 | 8 | 11 |
| CCND1 | Cyclin D1 | 9 | 18 |
| CHEK2 | Checkpoint kinase 2 | 10 | 17 |
| Bottom ten hits
| |||
|---|---|---|---|
| Gene symbol | Gene name | M-RAM rank | 2BHM rank |
|
| |||
| BRD4 | Bromodomain-containing protein 4 | 1, 4 | 12, 49 |
| EPHA2 | EPH receptor A2 | 2 | 1 |
| GRK1 | Rhodopsin kinase | 3 | 254 |
| PI4K2A | Phosphatidylinositol 4-kinase type 2 α | 5 | 246 |
| PFKFB1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | 6 | 98 |
| PIKFYVE | PI-3-phosphate/PI 5-kinase, type III | 7 | 25 |
| PRKCI | Protein kinase C ι | 8 | 633 |
| MID2 | Midline 2 | 9 | 29 |
| BRAF | V-raf murine sarcoma viral oncogene homolog B1 | 10 | 82 |