FIGURE 3.

Vorinostat normalizes gene expression of key components of cholesterol homeostasis. 80 ng of RNA from the indicated animals were assessed for gene expression at P60 using qRT-PCR relative to GAPDH (PCR primers are described under “Experimental Procedures”). Vehicle-treated WT mice were assigned a baseline expression of 1. a–g, cholesterol biosynthesis genes that were significantly enriched in RNA-Seq analysis (Hmgcs, Hmgcr, Mvk, Mvd, Idi1, Lss, and Cyp51). h, Ldlr. All groups are n = 3 with data shown as mean ± S.D. (error bars) *, p < 0.05, Student's t test.