FIGURE 1.

SNIPER(ER)s composed of various ERα and IAP ligands. A, structural schema of SNIPER(ER)s containing various ERα and IAP ligands. The detailed chemical structures of SNIPER compounds are provided in the supplemental material. B, protein knockdown activities of SNIPER(ER)s. C, effect of linker length on the protein knockdown activity of the MV1-based SNIPER(ER)s. MCF-7 cells were treated with the indicated concentrations of SNIPER(ER)s or a mixture of the ligands for 6 and 24 h. Whole-cell lysates were analyzed by Western blotting with the indicated antibodies. Numbers below the ERα panel represent the ERα/actin ratio normalized by the vehicle control as 100.