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. 2017 Jan 24;292(11):4571–4582. doi: 10.1074/jbc.M116.754929

FIGURE 9.

FIGURE 9.

P53/NF-κB/miR-375/HNF-1β pathway in cisplatin-induced apoptosis. Cisplatin treatment induces the activation of P53 and NF-κB, which further induce the expression of miR-375. miR-375 then represses the anti-apoptotic gene HNF-1β to induce apoptosis.