FIGURE 7.

Proteasome activity is not affected by GAPDH aggregation. A, reduction of trypsin-like and chymotrypsin-like protease activities caused by the treatment of SH-SY5Y cells with NOC18 for 48 h. Data are mean ± S.D. (n = 4). *, p < 0.05, **, p < 0.01, relative to vehicle treatment, Student's t test. B, effects of the overexpression of WT- and C152A-GAPDH on trypsin-like and chymotrypsin-like protease activities with NOC18 treatment. Data are mean ± S.D. (n = 4). n.s., not significant by Student's t test. A.U. indicates arbitrary units.