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. 2017 Feb 6;292(12):5043–5054. doi: 10.1074/jbc.M116.771014

FIGURE 2.

FIGURE 2.

Regulation of NFκB-dependent genes by vorinostat in ovarian cancer cells. A and B, real-time RT-PCR analysis of mRNA levels of the NFκB-regulated genes IL-8/CXCL8, CXCL5, TGFβ1, cIAP-1, Bcl-2, p65, p50, IκBα, CXCR1, and CXCR2 in SKOV3 (A) and CAOV3 (B) cells incubated with 1.5 μm vorinostat or control DMSO for 48 h. C, RT-PCR of IL-8 mRNA in CAOV3 cells incubated with increasing vorinostat concentrations for 48 h. D, RT-PCR of the above NFκB-regulated genes in OVCAR3 cells incubated with 1.5 μm vorinostat or DMSO for 48 h. E, RT-PCR of IL-8 mRNA in OVCAR3 cells incubated with increasing vorinostat concentrations for 48 h. The values represent the mean ± S.E. of four experiments. *, p < 0.05; **, p < 0.01; ***, p < 0.001 compared with control UT cells.