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. 2017 Feb 6;292(12):5043–5054. doi: 10.1074/jbc.M116.771014

FIGURE 8.

FIGURE 8.

Combination of vorinostat and Bay 117085 decreases IL-8/CXCL8 levels in vivo. A, IL-8 and TGFβ1 mRNA levels analyzed by real-time RT-PCR in excised tumors from the four treatment groups (n = 7). Vor, vorinostat. B, IL-8 and TGFβ1 release measured by ELISA in mouse plasma samples in the four treatment groups (n = 7) at the end of the experiment. C, representative Western blotting of tumor WCEs analyzed using antibodies against IL-8/CXCL8, TGFβ1, murine neutrophil [7/4] antigen, and actin. D, densitometry evaluation of IL-8/CXCL8, TGFβ1, and the murine neutrophil [7/4] antigen in tumor samples; the band intensities were normalized to actin (n = 5). The values represent the mean ± S.E. *, p < 0.05; **, p < 0.01; ***, p < 0.001).