FIGURE 9.

Proposed model of IL-8 regulation by HDAC and IKK in ovarian cancer cells. In ovarian cancer cells, the IL-8 promoter is occupied by an HDAC, which limits IL-8 transcription. Inhibition of HDAC activity increases IKKβ recruitment to the IL-8 promoter, facilitating recruitment of p65 NFκB and its acetylation, resulting in increased IL-8 transcription, cell survival, and proliferation. Inhibition of IKK activity decreases p65 recruitment to the IL-8 promoter, suppressing HDI-induced IL-8 expression.