Table 1.
Some possible effects of interest: When the control arm differs, we show the description of Design1/Design2.
| Description of Study Arms & Treatment Regimes | Trial | Units (Int. x Con.) | |||||
|---|---|---|---|---|---|---|---|
| Effects | Intervention | Control | Yrs | Design1 | Design2 | ||
| UTT before PrEP | UTT hia | A1 = 1 | UTT lowb | A1 = 0 | 0–3 | 16x16 | 16x16 |
| PrEP in UTT intervention arm | UTT hia+PrEP hic | A = (1, 1) | UTT hia | A = (1, 0) | 3–7 | 8x8 | 8x8 |
| PrEP in UTT control arm | UTT low-to-hid+PrEP hic | A = (0, 1) | UTT low-to-hid | A = (0, 0) | 3–7 | NA | 8x8 |
| UTT without PrEP | UTT hia | A = (1, 0) | UTT lowb/low-to-hid | A = (0, 0) | 0–7 | 8x16 | 8x8 |
| UTT with PrEP | UTT hia+PrEP hic | A = (1, 1) | UTT low-to-hid+PrEP hic | A = (0, 1) | 0–7 | NA | 8x8 |
| Main PrEP effecte | PrEP hic | A2 = 1 | Std. of care PrEP | A2 = 0 | 3–7 | NA | 16x16 |
| Main UTT effectf | UTT hia | A1 = 1 | UTT low-to-hid | A1 = 0 | 0–7 | NA | 16x16 |
| Joint UTT & PrEP effect | UTT hia+PrEP hic | A = (1, 1) | UTT lowb/low-to-hid | A = (0, 0) | 0–7 | 8x16 | 8x8 |
Int.: Intervention arm; Con.: Control arm; Yrs.: Years; UTT: universal test-and-treat; hi: high; Std.: Standard
A1: first randomization assignment; A2: second randomization assignment; A = (A1, A2): joint treatment assignment
UTT with high coverage: 85% of HIV+ on antiretroviral therapy & suppressed
UTT with low coverage: 55% of HIV+ on antiretroviral therapy & suppressed
PrEP with high coverage: 85% of eligible HIV- on PrEP & adherent
UTT with low coverage (55%) until year 3, then UTT with high coverage (85%) - Design 2 only
This comparison averages or collapses over the UTT arms: A = (1, 1) & A = (0, 1) versus A = (1, 0) & A = (0, 0)
This comparison averages or collapses over the PrEP arms: A = (1,1) & A = (1,0) versus A = (0,1) & A = (0,0)