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. 2016 Oct 18;146(5):530–537. doi: 10.1093/ajcp/aqw142

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© American Society for Clinical Pathology, 2016.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Representative examples of colocalization of MUC5AC and TFF1 in different hyperplastic polyps (HPs) (A) and sessile serrated adenomas/polyps (SSA/Ps) (B) (x20). Compared with HPs, most SSA/P samples showed significant colocalization often approaching 100%. HPs also exhibited greater variability in the distribution and colocalization of signals. Expression of MUC5AC and TFF1 was generally observed in separate cells with little colocalization. Two of 46 HPs analyzed demonstrated more coexpression of MUC5AC and TFF1 suggestive of but not identical to SSA/Ps (A, bottom row).