Table IV.

Potential interactions between peripheral blood leucocyte telomere length (TL) and HCC risk factors.

HCC risk factors/TLs	N (%)		Crude OR (95% CI)	OR* (95% CI)
	Cases	Controls
HBsAg/TL, N=794
HBsAg(−)/Longer	59 (22.3)	215 (40.6)	1.00 (Reference)	1.00 (Reference)
HBsAg(−)/Shorter	38 (14.3)	179 (33.8)	1.08 (0.64–1.84)	1.00 (0.53–1.86)
HBsAg(+)/Longer	65 (24.5)	50 (9.4)	5.47 (3.23–9.25)**	7.85 (4.17–14.80)**
HBsAg(+)/Shorter	103 (38.9)	85 (16.2)	6.36 (3.74–10.81)**	6.30 (3.45–11.51)**
RER (95% CI)			0.81 (−2.11 to 3.73)	−1.55 (−4.57 to 1.47)
Anti-HCV/TL, N=703
Anti-HCV(−)/Shorter	105 (43.8)	221 (47.6)	1.00 (Reference)	1.00 (Reference)
Anti-HCV(−)/Longer	74 (31.0)	199 (42.9)	0.74 (0.48–1.12)	0.97 (0.59–1.60)
Anti-HCV(+)/Shorter	30 (12.6)	30 (6.5)	2.46 (1.30–4.67)**	4.64 (2.13–10.11)**
Anti-HCV(+)/Longer	30 (12.6)	14 (3.0)	6.51 (2.68–15.82)**	11.47 (4.10–32.08)**
RER (95% CI)			4.32 (1.66 to 6.97)	6.86 (2.34 to 11.40)
Cigarette smoking/TL, N=800
Never/Longer	84 (31.3)	181 (34.0)	1.00 (Reference)	1.00 (Reference)
Never/Shorter	79 (29.5)	152 (28.6)	1.20 (0.78–1.84)	0.74 (0.419–1.34)
Ever/Longer	40 (14.9)	85 (16.0)	1.06 (0.63–1.80)	0.74 (0.37–1.46)
Ever/Shorter	65 (24.3)	114 (21.4)	1.37 (0.83–2.27)	0.82 (0.43–1.59)
RER (95% CI)			0.11 (−0.67 to 0.89)	0.36 (−0.16 to 0.87)
Alcohol drinking/TL, N=799
Never/Longer	110 (41.2)	239 (44.9)	1.00 (Reference)	1.00 (Reference)
Never/Shorter	110 (41.2)	229 (43.0)	1.12 (0.77–1.63)	0.81 (0.49–1.32)
Ever/Longer	14 (5.2)	27 (5.1)	1.15 (0.57–2.33)	1.20 (0.50–2.89)
Ever/Shorter	33 (12.4)	37 (7.0)	2.27 (1.25–4.13)**	1.96 (0.92–4.19)
RER (95% CI)			1.00 (0.13 to 1.87)	0.95 (0.21 to 1.69)

^*OR adjusted for age, gender and other three HCC risk factors except for the factor that has potential modification effect with TL;

^**p<0.01.