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. 2017 Apr 3;7:45725. doi: 10.1038/srep45725

Figure 5. Comparison of intracellular TFV-DP levels in epithelial cells to evaluate TFV and TAF effects on barrier function and wound closure.

Figure 5

(a) Measurement of intracellular TFV-DP levels in EM epithelial cells following incubation with different doses of TFV (black dots, minimum of n = 3 for each time point) or TAF (grey dots, n = 3 for each time point) for 24 h. (b and c) TER measurement of EM epithelial cells treated with selected doses of TFV (b) or TAF (c) that match intracellular concentrations of TFV-DP. Representative of 3 experiments with different donors. Dots represent the mean from triplicate cultures. ***p < 0.001. (d) % wound closure after treatment with matched doses of TFV (black bars) and TAF (grey bars). Bars represent mean ± SEM from 4 independent experiments with different donors. *p < 0.05. ***p < 0.001.