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. 2017 Jan 16;35(Suppl 1):S24–S32. doi: 10.1097/HJH.0000000000001241

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Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0

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Distribution of genotyped ADVANCE study participants (n = 3409) according to principal components of genotype structure using EIGENSOFT 3.0 package. (a) ADVANCE individuals are plotted against the first two principal components PC1 (west–east gradient) and PC2 (north–south gradient), (b) frequency distribution of study participants by value of PC1. (c) Distribution of principal component values by countries of recruitment of patients in ADVANCE. (d) ADVANCE recruitment centers ordered by mean value of PC1.