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. 2017 Jan 16;35(Suppl 1):S24–S32. doi: 10.1097/HJH.0000000000001241

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Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0

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Effect of ethnic origin (Celtic vs. Slavic) and environment (Celtic region vs. Slavic region) on age of onset of T2D, SBP, UACR, and eGFR_CKD-EPI. Age of onset of T2D (a) and UACR (c) are more linked to genetics whereas SBP (b) and eGFR_CKD-EPI (d) are more impacted by environmental factors. Age of onset of T2D is adjusted for sex whereas all other traits are adjusted for sex, age, and treatment (nonparametric adjustment [34]). eGFR_CKD-EPI, estimated glomerular filtration rate calculated using Chronic Kidney Disease Epidemiology Collaboration equation; PC, principal component; UACR, urinary albumin–creatinine ratio; T2D, type 2 diabetes.