FIGURE 4.

Distribution of the CC genotype frequencies for rs340841 located at the PROX1 locus in Celtic (a) and Slavic (b) study participants separately. Histograms of means of age of onset of T2D vs. genotype of rs340841 (inserts). Regional association plots (1Mb window) of the PROX1 locus (chromosome 1) identified by GWAS of age of onset of T2D in Celtic (c) and Slavic (d) study participants, respectively. −log₁₀ (P values) are plotted against genomic position (build 37, hg19). The lead SNP (rs340841) is indicated in purple diamond. The SNPs surrounding rs340841 are color coded based on their linkage disequilibrium with the lead SNP (taken from pairwise r² values from the 1000 Genome EUR Database): red (r² with lead SNP 0.8–1.0), orange (0.6–0.8), green (0.4–0.6), light blue (0.2–0.4), and dark blue (<0.2). The recombination rates (cM/Mb) are plotted in blue to reflect local linkage disequilibrium structure. Genes, exons, and direction of transcription from UCSC genome browser (genome.ucsc.edu) are noted. Plots are generated using LocusZoom (http://csg.sph.umich.edu/locuszoom). GWAS, genome-wide association studies; SNP, single-nucleotide polymorphism; T2D, type 2 diabetes.