Figure 1.

Structural organization of human p53. (A) Alternative splicing forms of the Trp53 gene. (B) Organization of the 393 residues of p53 protein into three major regions. (C) The sites of the most frequent posttranslational modifications are distributed all along the sequence, with the greatest concentrations at the transactivation domains (TADs), in the amino-terminal and carboxy-terminal domain (CTD) in the carboxy terminal. They include phosphorylation, acetylation, ubiquitination, methylation, neddylation, and sumoylation. PRR, Proline-rich region; DBD, DNA-binding domain; OD, oligomerization domain.