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. 2017 Apr;27(4):553–566. doi: 10.1101/gr.212050.116

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© 2017 Sarda et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 6. — Functional enrichment of MethExp genes in cancer that potentially utilize an upstream CGI as a promoter. GO terms are shown on the y-axis, along with their corresponding −log(adjusted P) significance measures on the x-axis. Solid black line at P = 0.05 represents the threshold for enrichment. (A,B) Functional enrichment for genes whose promoters are broadly hypermethylated across samples but whose expression across samples is correlated with the upstream CGI's methylation and not that of the proximal promoter, in breast cancer (A), and (B) in kidney cancer. (C) Functional enrichment in genes whose differential expression between normal and breast cancer samples is correlated with the methylation status of the upstream CGIs and not with that of the proximal promoter.