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. 2017 Apr;27(4):567–579. doi: 10.1101/gr.198044.115

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© 2017 Wang et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 4. — Feedback loops extracted from NP networks of monkey, human, and mouse. (A) The largest feedback loop in the monkey. The three-node loops were explored by requiring at least one negative edge within the loop. Red or green edges represent that the two nodes are transcriptionally correlated or anti-correlated, respectively. Node color indicates the module to which the gene belongs. Node shape indicates whether a gene is related (hexagon) or unrelated (circle) to the DNA damage response (DDR). (B) The largest feedback loop in humans. (C) The largest feedback loop in the mouse. This figure is based on monkey individual-oocyte/embryo sequencing data. Similar results for the pooled-embryo data are shown in Supplemental Figure S9.

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