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Branchpoint location predetermines the 3′ss choice in wild-type and SF3B1 mutant background. (A) Branchpoint location relative to the 3′ss analyzed in transcripts undergoing alternative 3′ss usage across ENCODE cell lines. Transcripts in cell lines using predominantly the upstream 3′ss (top) are compared to branchpoint usage in cases where the downstream 3′ss is used (bottom). (B) Branchpoint to 3′ss distance analyzed in wild type or the oncogenic mutant SF3B1 K700E NALM-6 cell line.
