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. 2017 Mar 7;108(3):354–361. doi: 10.1111/cas.13139

Figure 6.

Figure 6

Changes in cell proliferation, migration, and invasion in cells expressing mutant nestin (a) MIA PaCa‐2 cells transfected with mut‐nes1, 2, or 3 showed decreases in cell proliferation (*P < 0.05 vs. non‐transfected and EV‐transfected cells). (b, c) MIA PaCa‐2 cells transfected with wild‐type nestin or mut‐nes1 show an increase in cell migration and invasion, but cells expressing mut‐nes2 and 3 showed a decrease in migration and invasion (#P < 0.05 vs. non‐transfected, EV, and mut‐nes‐2, 3 cells). (d) PANC‐1 cells transfected with mut‐1,2, or 3 showed a decrease of cell proliferation (*P < 0.05 vs. non‐transfected and EV cells). (e,f) PANC‐1 cells transfected with wild‐type nestin or mut‐nes1 show an increase in cell migration and invasion, but cells expressing mut‐nes2 and 3 showed a decrease in migration and invasion (#P < 0.05 vs. non‐transfected, EV, and mut‐nes‐2, 3 cells).