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. 2017 Apr 3;108(3):338–346. doi: 10.1111/cas.13167

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© 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Confirmation of rat model with cirrhosis and hepatocellular carcinoma (HCC) and experimental manipulation. (a) Images of hepatic cirrhosis and HCC confirmed by naked eye. HE from representative cases are shown (HE original magnification, 200×). (b) Interference of adenovirus injection and partial hepatectomy were performed. ① Rats of the miR‐203+PH group were injected with recombinant miR‐203 overexpression adenovirus through the penis vein. ② HCC nodules were observed after abdominal incision. ③ Partial hepatectomy was performed in the rats of the miR‐203+PH, miR‐NC+PH, and PH groups. ④ Liver specimen of left lobe resected by partial hepatectomy. (c) Time course of the animal model experiment.