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. 2017 Apr 3;108(3):373–379. doi: 10.1111/cas.13151

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© 2016 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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POTEF‐AS1 inhibits Toll‐like receptor (TLR) signaling and apoptosis‐related genes. (a) Knockdown efficiency of POTEF‐AS1 by siRNA, analyzed by quantitative RT‐PCR (n = 3) in LNCaP and LTAD cells treated with 10 nM 5α‐dihydrotestosterone (DHT) or ethanol (Et) for 18 h. LNCaP and LTAD cells were transfected with 20 nM and 50 nM siRNA, respectively. The value of vehicle and negative control siRNA (siNC)‐treated cells was set to 1. (b) TLR3 and TNFSF10 mRNA expressions analyzed by quantitative RT‐PCR in LNCaP and LTAD cells treated with Et or 10 nM DHT for 24 h. (c) TLR3 and TNFSF10 mRNA expression in siPOTEF‐AS1 or siNC‐transfected LNCaP (20 nM siRNA) cells for 24 h. Values represent mean ± SD. *P < 0.05; **P < 0.01.