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. 2017 Apr 3;108(3):448–454. doi: 10.1111/cas.13150

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© 2016 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Initial cirExo‐TRPC5 level (cirExo‐TRPC5 level before chemotherapy) was significantly correlated with tumor response. (a) Median mean of cirExo‐TRPC5 levels in responders was significantly lower than in non‐responders (P < 0.05). (b) Pearson correlation analysis showed that initial cirExo‐TRPC5 levels were significantly negatively correlated with the tumor shrinkage ratio (P < 0.05). Student's t‐test showed no significant change of cirExo‐TRPC5 level after chemotherapy in the 91 patients who achieved complete response (CR)/partial response (PR)/stable disease (SD) (P = 0.47) (c) and in the 40 patients who achieved progressive disease (PD) (P = 0.41) (d).