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Increased cirExo‐TRPC5 level after chemotherapy predicted acquired chemoresistance. Metastatic breast cancer patients with a cirExo‐TRPC5 increase of more than 1.09 times (n = 36) after the first 2 chemotherapy cycles showed a significantly shorter progression free survival than patients with a cirExo‐TRPC5 increase of not more than 1.09 times (n = 55) (log‐rank, P = 0.0042).
