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siRNA‐mediated TOPK knockdown results in decrease of cell viability in SCLC cells. Real‐time RT‐PCR (a) and western blot (b) analyses were conducted to examine expression levels of TOPK and TOPK protein levels in six adherent SCLC cells at 48 h after transfection with control siRNA or TOPK siRNA (*P < 0.05; **P < 0.01). (c) MTT assays were performed 6 days after transfection with siRNAs (*P < 0.05; **P < 0.01; ***P < 0.001).
