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. 2017 Apr 3;108(3):478–487. doi: 10.1111/cas.13138

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© 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Verteporfin inhibits angiogenesis by downregulating Ang2 expression. (a–c) Human umbilical vein endothelial cells (HUVECs) were pre‐treated with verteporfin at 4 μM concentration for 24 h. Cell migration was analyzed by transwell assays (Magnification ×100, bar = 100 μM) (a), and angiogenesis by tube formation assays (Magnification ×40) (b) and by chorioallantoic membrane assays (c). (d, e) The expression of Ang2 and CD31 was detected by IHC (Magnification ×400, bar = 25 μM). Data were presented as mean ± SD. *P < 0.05; **P < 0.01; ***P < 0.001.