Table 1.

Variable definitions used in the original study by Opal et al (12)

Variable	Definition
Shock	Either of the following: Systolic blood pressure ≤ 90 mm H, mean arterial pressure ≤ 70 mm Hg, decrease in systolic blood pressure ≥ 40 mmHg Persistent need for vasopressor agents to maintain blood pressure (excluding dopamine at dosages < 5.0 μg/kg per minute) despite adequate fluid resuscitation. if vasopressor agents were administered and the systolic blood pressure was 120 mm Hg or greater: no shock
DIC	Both criteria: No anti-coagulation: PT or PTT ≥ 1.2 × normal value Platelet count ≤ 100xl09/L or ≥ 50% decrease in platelet count. With therapeutic doses of warfarin or heparin: Abnormal platelet counts (above) and Elevated fibrin split products or the D-dimer ≥ 0.5 mg/L.
AKI	Either of the following Serum creatinine concentration ≥ 177 mmol/L (≥ 2.0 mg/dL) Need for dialysis Pre-existing renal dysfunction: ≥ 177 mmol/L (≥ 2.0 mg/dL) increase in the serum creatinine concentration
HBD	At least two of the following: Total serum bilirubin concentration ≥ 43 mmol/L (≥ 2.5 mg/dL) Serum concentration of AST or ALT ≥ 2 × upper limit normal PT≥ 1.5 × normal value
ARDS	According to criteria of Murray, et al (47)

DIC: disseminated intravascular coagulation

PT: prothrombin time

PTT: partial thromboplastin time

HBD: hepatobiliary dysfunction

ARDS: acute respiratory distress syndrome

AKI: acute kidney injury

AST: aspartate aminotransferase

ALT: alanine aminotransferase