Table 1.
Characteristics of SPIROMICS Participants without Airflow Obstruction (N = 1,066)
| All Subjects | Without Respiratory Impairment* (n = 580) | With Respiratory Impairment* (n = 486) | |
|---|---|---|---|
| Demographics | |||
| Age, yr, mean (SD) | 60.1 (9.9) | 60.2 (10.0) | 59.9 (9.8) |
| Females, %† | 53.3 | 49.5 | 57.8 |
| African American, %† | 24.2 | 19.7 | 29.6 |
| Body mass index, kg/m2, mean (SD)† | 28.8 (5.1) | 28.0 (4.7) | 29.6 (5.4) |
| Smoking status | |||
| Never-smokers, %† | 17.2 | 26.6 | 6.0 |
| Former smoker, % | 42.6 | 43.3 | 41.8 |
| Currently smoking, %† | 40.2 | 30.1 | 52.2 |
| Smoking history | |||
| Pack-years smoked, mean (SD)† | 36.2 (27.3) | 30.6 (25.9) | 42.9 (27.5) |
| Respiratory function | |||
| FEV1, L, mean (SD)† | 2.78 (0.73) | 2.92 (0.71) | 2.61 (0.71) |
| FEV1 % predicted, mean (SD)† | 96.3 (13.7) | 99.3 (12.9) | 92.7 (13.8) |
| Comorbidities, % | |||
| Hypertension† | 42.4 | 37.1 | 48.8 |
| Anxiety or depression† | 32.2 | 24.7 | 41.2 |
| Gastroesophageal reflux disease† | 28.0 | 23.4 | 33.5 |
| Diabetes mellitus† | 12.5 | 7.9 | 17.9 |
| Asthma† | 15.0 | 6.2 | 25.5 |
| Coronary artery disease | 4.7 | 3.3 | 6.4 |
| Sleep apnea† | 16.4 | 14.5 | 18.7 |
| Peripheral vascular disease† | 5.6 | 2.6 | 9.3 |
Definition of abbreviation: SPIROMICS = Subpopulations and Intermediate Outcome Measures in COPD Study.
*
Participants were considered to be without respiratory-related impairment (21) if they did not report chronic bronchitis symptoms (22), dyspnea score greater than or equal to two on the modified Medical Research Council scale (23), distance walked in 6 minutes greater than 350 m, St. George’s Respiratory Questionnaire total score less than or equal to 25 points (24), and acute respiratory events in the year before enrollment, defined as use of antibiotic and/or steroid or hospital admission for a respiratory “flare-up.”
†
P less than 0.05.