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. 2017 Mar 28;10:1875–1888. doi: 10.2147/OTT.S130147

Table 1.

Characteristics of studies included in the meta-analysis

Study Year Country/region Ethnicity Gene SNP Case
Disease group Control
Source of controls HWE, P-value Genotyping methods NOS score
MM/Mm/mm MM/Mm/mm
Ahn et al39 2002 South Korea Asian MTHFR rs1801133 16/13/3 Meningioma 91/129/34 PB 0.27 PCR-RFLP 7
Bethke et al38 2009 Finland Caucasian CASP8 rs1045485 60/16/0 Meningioma 65/7/0 PB 0.66 Illumina customized GoldenGate array 7
Denmark Caucasian CASP8 rs1045485 81/20/0 84/23/1 PB 0.67
UK – South Caucasian CASP8 rs1045485 92/21/6 93/24/1 PB 0.68
UK – North Caucasian CASP8 rs1045485 128/37/2 133/29/4 PB 0.13
Sweden Caucasian CASP8 rs1045485 115/27/2 115/27/1 PB 0.67
Bethke et al37 2008 UK – North Caucasian MTHFR rs1801131 80/73/20 Meningioma 94/64/17 PB 0.22 Illumina GoldenGate array 7
UK – North Caucasian MTHFR rs1801133 57/98/19 73/78/24 PB 0.66
UK – North Caucasian MTRR rs1801394 54/83/37 74/78/23 PB 0.73
UK – North Caucasian MTR rs1805087 113/54/7 106/60/8 PB 0.89
UK – Southeast Caucasian MTHFR rs1801131 54/59/8 62/48/13 PB 0.42
UK – Southeast Caucasian MTHFR rs1801133 50/57/14 48/60/15 PB 0.57
UK – Southeast Caucasian MTRR rs1801394 41/57/23 39/59/25 PB 0.76
UK – Southeast Caucasian MTR rs1805087 77/39/5 75/42/6 PB 0.97
Sweden Caucasian MTHFR rs1801131 61/77/11 64/66/19 PB 0.76
Sweden Caucasian MTHFR rs1801133 64/68/17 82/57/10 PB 0.98
Sweden Caucasian MTRR rs1801394 39/84/26 53/74/22 PB 0.64
Sweden Caucasian MTR rs1805087 98/45/6 94/51/4 PB 0.34
Denmark Caucasian MTHFR rs1801131 44/57/9 53/43/17 PB 0.1
Denmark Caucasian MTHFR rs1801133 45/55/10 56/45/12 PB 0.52
Denmark Caucasian MTRR rs1801394 41/47/22 40/55/18 PB 0.90
Denmark Caucasian MTR rs1805087 73/33/4 70/40/3 PB 0.33
Finland Caucasian MTHFR rs1801131 38/31/8 37/32/8 PB 0.78
Finland Caucasian MTHFR rs1801133 46/26/5 47/25/5 PB 0.51
Finland Caucasian MTRR rs1801394 26/37/14 30/33/14 PB 0.36
Finland Caucasian MTR rs1805087 50/24/3 56/17/4 PB 0.1
Cacina et al36 2015 Turkey Caucasian CASP8 rs1045485 28/8/3 Meningioma 66/42/6 PB 0.84 PCR-RFLP 7
Cengiz et al35 2008 Turkey Caucasian XRCC1 rs25487 25/41/5 Meningioma 43/41/3 PB 0.07 PCR-RFLP 8
De Roos et al34 2003 US Caucasian GSTM1 Present/null 85b/84c Meningioma 254b/321c HB – PCR 7
GSTT1 Present/null 121b/38c 445b/100c HB –
Dobbins et al33 2011 Germany Caucasian MLLT10 rs12770228 309/426/123 Meningioma 328/302/74 PB 0.72 a 7
UK Caucasian MLLT10 rs12770228 144/187/73 361/321/76 PB 0.71
Scandinavia Caucasian MLLT10 rs12770228 145/158/47 463/424/91 PB 0.67
Egan et al32 2015 US Caucasian MLLT10 rs12770228 111/111/46 Meningioma 287/267/74 PB 0.33 TaqMan assays 7
Elexpuru-Camiruaga et al31 1995 UK Caucasian GSTM1 Present/null 22b/27c Meningioma 262b/315c HB – PCR 7
UK Caucasian GSTT1 Present/null 26b/21c 403b/91c HB –
Huang et al30 2012 China Asian XRCC1 rs1799782 100/80/25 Meningioma 95/102/21 PB 0.39 Snapshot multiplex 8
China Asian XRCC1 rs1799782 53/24/11 <50 years old 41/51/12 PB 0.52
China Asian XRCC1 rs1799782 47/56/14 ≥50 years old 54/51/9 PB 0.52
China Asian XRCC1 rs1799782 27/20/7 Male 29/36/9 PB 0.67
China Asian XRCC1 rs1799782 73/60/18 Female 66/66/12 PB 0.42
Huang et al29 2015 China Asian XRCC1 rs1799782 63/41/20 Skull-base meningioma 95/102/21 PB 0.39 Snapshot multiplex 8
Kafadar et al28 2006 Turkey Caucasian MTHFR rs1801133 20/12/3 Meningioma 53/38/7 PB 0.96 PCR-RFLP 9
Kiuru et al27 2008 Mixed Caucasian XRCC1 rs1799782 469/50/2 Meningioma 1,377/177/2 PB 0.13 PCR-RFLP 9
Mixed Caucasian XRCC1 rs25487 212/233/74 645/728/176 PB 0.17
Li et al26 2013 China Asian MTHFR rs1801133 101/147/69 Meningioma 159/129/32 PB 0.44 PCR-RFLP 9
China Asian MTHFR rs1801131 205/96/16 201/98/21 PB 0.06
Pinarbasi et al25 2005 Turkey Caucasian GSTM1 Present/null 12b/11c Meningioma 116b/37c HB – PCR 7
Turkey Caucasian GSTT1 Present/null 17b/6c 122b/31c HB –
Rajaraman et al24 2010 US Caucasian XRCC1 rs1799782 104/18/0 Meningioma 394/73/1 HB 0.21 TaqMan assay 7
US Caucasian XRCC1 rs25487 56/62/14 205/201/72 HB 0.05
Rajaraman et al23 2007 US Caucasian CASP8 rs1045485 117/38/5 Meningioma 426/118/6 HB 0.87 Medium-throughput TaqMan assay 7
Schwartzbaum et al22 2007 Mixed Caucasian GSTM1 Present/null 68b/108c Meningioma 193b/237c PB – PCR 8
Mixed Caucasian GSTT1 Present/null 149b/27c 362b/68c PB –
Semmler et al21 2008 Germany Caucasian MTHFR rs1801133 131/133/26 Meningioma 132/135/20 PB 0.06 PCR-RFLP 8
Germany Caucasian MTHFR rs1801131 116/142/32 Meningioma 132/123/32 PB 0.68
Germany Caucasian MTR rs1805087 197/81/12 Meningioma 184/92/11 PB 0.91
Germany Caucasian MTHFR rs1801133 10/7/1 WHO grade III 132/135/20 PB 0.91
Germany Caucasian MTHFR rs1801131 7/10/1 WHO grade III 132/123/32 PB 0.91
Germany Caucasian MTR rs1805087 18/0/0 WHO grade III 184/92/11 PB 0.91
Zhang et al20 2013 China Asian MTHFR rs1801131 184/157/50 WHO grade I 289/245/66 PB 0.2 PCR-RFLP 8
China Asian MTRR rs1801394 135/176/80 WHO grade I 225/282/93 PB 0.77
China Asian MTHFR rs1801131 79/67/21 WHO grade II 289/245/66 PB 0.2
China Asian MTRR rs1801394 59/74/34 WHO grade II 225/282/93 PB 0.77
China Asian MTHFR rs1801131 20/17/5 WHO grade III 289/245/66 PB 0.2
China Asian MTRR rs1801394 15/19/8 WHO grade III 225/282/93 PB 0.77

Notes: M, major allele; m, minor allele.

a

Illumina Infinium HD human 662 quad or OmniExpress BeadChip, competitive allele-specific KASP chemistry;

b

number of samples with GSTM1 or GSTT1 null genotype;

c

number of samples with GSTM1 or GSTT1 null/present genotype. ‘–’ indicates not available.

Abbreviations: SNP, single-nucleotide polymorphism; HWE, Hardy–Weinberg Equilibrium; NOS, Newcastle–Ottawa Scale; PB, population-based; PCR-RFLP, polymerase chain reaction–restriction fragment-length polymorphism; HB, hospital-based; WHO, World Health Organization.