Table 3.
Pooled analysis of the associations between MLLT10, CASP8, XRCC1, MTHFR, MTRR, and MTR polymorphisms and meningioma risk
| Gene | SNP | Comparison | Number of studies | Sample size
|
Test of association
|
Heterogeneity
|
Model | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Case | Control | OR (95% CI) | P-value | I2 | P-value | |||||
| MLLT10 | rs12770228 | A vs G | 4 | 1,880 | 3,068 | 1.36 (1.24–1.48) | <0.001 | 16.6 | 0.309 | F |
| AA vs GG | 4 | 1,880 | 3,068 | 1.84 (1.53–2.23) | <0.001 | 0 | 0.438 | F | ||
| GA vs GG | 4 | 1,880 | 3,068 | 1.32 (1.13–1.54) | <0.001 | 27.7 | 0.246 | R | ||
| GA+AA vs GG | 4 | 1,880 | 3,068 | 1.42 (1.23–1.64) | <0.001 | 28.7 | 0.24 | R | ||
| AA vs GG+GA | 4 | 1,880 | 3,068 | 1.36 (1.24–1.48) | <0.001 | 0 | 0.552 | F | ||
| CASP8 | rs1045485 | C vs G | 7 | 806 | 1,271 | 1.14 (0.94–1.4) | 0.181 | 2.6 | 0.406 | F |
| CC vs GG | 6 | 730 | 1,199 | 1.67 (0.86–3.26) | 0.129 | 5.5 | 0.382 | F | ||
| GC vs GG | 7 | 806 | 1,271 | 1.06 (0.8–1.4) | 0.687 | 26.4 | 0.227 | R | ||
| GC+CC vs GG | 7 | 806 | 1,271 | 1.11 (0.89–1.39) | 0.181 | 14.7 | 0.318 | F | ||
| CC vs GG+GC | 6 | 730 | 1,199 | 1.14 (0.94–1.4) | 0.102 | 3.6 | 0.393 | F | ||
| XRCC1 | rs1799782 | T vs C | 8 | 1,382 | 2,896 | 0.94 (0.82–1.07) | 0.327 | 0 | 0.469 | F |
| TT vs CC | 8 | 1,382 | 2,896 | 1.22 (0.89–1.69) | 0.219 | 0 | 0.83 | F | ||
| CT vs CC | 8 | 1,382 | 2,896 | 0.75 (0.61–0.94) | 0.010 | 34.2 | 0.155 | R | ||
| CT+TT vs CC | 8 | 1,382 | 2,896 | 0.82 (0.7–0.97) | 0.018 | 23.8 | 0.24 | F | ||
| TT vs CC+CT | 8 | 1,382 | 2,896 | 1.43 (1.05–1.95) | 0.022 | 0 | 0.969 | F | ||
| XRCC1 | rs25487 | A vs G | 3 | 722 | 2,114 | 1.08 (0.89–1.31) | 0.440 | 37 | 0.205 | R |
| AA vs GG | 3 | 722 | 2,114 | 1.14 (0.67–1.95) | 0.632 | 49.3 | 0.139 | R | ||
| GA vs GG | 3 | 722 | 2,114 | 1.09 (0.85–1.4) | 0.495 | 27.8 | 0.25 | R | ||
| GA+AA vs GG | 3 | 722 | 2,114 | 1.1 (0.87–1.39) | 0.429 | 25.3 | 0.262 | R | ||
| AA vs GG+GA | 3 | 722 | 2,114 | 1.09 (0.63–1.86) | 0.766 | 54.2 | 0.112 | R | ||
| MTHFR | rs1801133 | T vs C | 10 | 1,323 | 1,883 | 1.14 (0.93–1.39) | 0.222 | 64.2 | 0.003 | R |
| TT vs CC | 10 | 1,323 | 1,883 | 1.31 (0.87–1.98) | 0.201 | 52 | 0.027 | R | ||
| CT vs CC | 10 | 1,323 | 1,883 | 1.19 (0.95–1.49) | 0.132 | 43.8 | 0.066 | R | ||
| CT+TT vs CC | 10 | 1,323 | 1,883 | 1.19 (0.92–1.53) | 0.180 | 58.9 | 0.009 | R | ||
| TT vs CC+CT | 10 | 1,323 | 1,883 | 1.22 (0.87–1.71) | 0.239 | 36.6 | 0.115 | R | ||
| MTHFR | rs1801131 | C vs A | 11 | 1,855 | 3,331 | 1.05 (0.95–1.15) | 0.335 | 0 | 0.97 | F |
| CC vs AA | 11 | 1,855 | 3,331 | 1.01 (0.82–1.24) | 0.597 | 0 | 0.829 | F | ||
| AC vs AA | 11 | 1,855 | 3,331 | 1.13 (0.99–1.29) | 0.060 | 0 | 0.793 | F | ||
| AC+CC vs AA | 11 | 1,855 | 3,331 | 1.11 (0.98–1.25) | 0.108 | 0 | 0.935 | F | ||
| CC vs AA+AC | 11 | 1,855 | 3,331 | 0.94 (0.77–1.15) | 0.574 | 0 | 0.594 | F | ||
| MTRR | rs1801394 | G vs A | 8 | 1,231 | 2,437 | 1.18 (1.06–1.31) | 0.002 | 0 | 0.682 | F |
| GG vs AA | 8 | 1,231 | 2,437 | 1.4 (1.14–1.73) | 0.002 | 0 | 0.756 | F | ||
| AG vs AA | 8 | 1,231 | 2,437 | 1.1 (0.93–1.3) | 0.250 | 0 | 0.67 | F | ||
| AG+GG vs AA | 8 | 1,231 | 2,437 | 1.18 (1.01–1.37) | 0.036 | 0 | 0.622 | F | ||
| GG vs AA+AG | 8 | 1,231 | 2,437 | 1.33 (1.1–1.61) | 0.003 | 0 | 0.883 | F | ||
| MTR | rs1805087 | G vs A | 7 | 939 | 1,210 | 0.89 (0.75–1.04) | 0.140 | 0 | 0.51 | F |
| GG vs AA | 7 | 939 | 1,210 | 0.96 (0.6–1.53) | 0.867 | 0 | 0.985 | F | ||
| AG vs AA | 7 | 939 | 1,210 | 0.84 (0.69–1.02) | 0.074 | 10.4 | 0.35 | F | ||
| AG+GG vs AA | 7 | 939 | 1,210 | 0.85 (0.7–1.02) | 0.084 | 5.7 | 0.384 | F | ||
| GG vs AA+AG | 7 | 939 | 1,210 | 1.02 (0.64–1.61) | 0.946 | 0 | 0.986 | F | ||
Abbreviations: SNP, single-nucleotide polymorphism; OR, odds ratio; CI, confidence interval; F, fixed; R, random; A, adenine; G, guanine; C, cytosine; T, thymine.