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. 2017 Mar 28;12:2407–2425. doi: 10.2147/IJN.S131367

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© 2017 Liu et al. This work is published and licensed by Dove Medical Press Limited

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Rational construction of TF-CPP-SSL.

Notes: (A) Cellular uptake of TF_X-CPP_Y-SSL-loaded courmarin-6 on BMVECs, X and Y represent the molecular weight of PEG linked to TF and CPP, respectively. (B) Effect of TF density on cellular uptake ratio of TF_3.4K-SSL-loaded courmarin-6 on BMVECs and C6, respectively. (C) Effect of CPP density on cellular uptake of TF_3.4K-CPP_2K-SSL-loaded courmarin-6 on presaturated glioma C6 cells. **P<0.01, data were expressed by mean ± SD (n=3). TF_3.4K-SSL, transferrin linked to PEG_3.4K-modified liposome; TF_3.4K-CPP_2K-SSL, transferrin linked to PEG_3.4K and cell penetrating peptide linked to PEG_2K-modified liposome.

Abbreviations: TF, transferrin; CPP, cell penetrating peptide (G2R9); SSL, sterically stabilized liposome; BMVECs, brain microvascular endothelial cells; PEG, polyethylene glycol; FI, fluorescence intensity.