Table 2.

ANOVA fitting quadratic model for four main responses

Response	Course	F-value	P-value	Data evaluation
R1, particle size	Model	186.34	<0.0001	Significant
	Linear mixture	519.25	<0.0001
	X1 X2	0.04	0.8473
	X1 X3	10.17	0.0097
	X1 X4	1.76	0.2143
	X2 X3	7.70	0.0196
	X2 X4	1.97	0.1903
	X3 X4	9.44	0.0118
	Lack of fit	0.26	0.9161	Not significant
R2, PDI	Model	22.57	<0.0001	Significant
	Linear mixture	55.87	<0.0001
	X1 X2	0.84	0.3807
	X1 X3	2.07	0.1806
	X1 X4	10.09	0.0099
	X2 X3	2.60	0.1379
	X2 X4	0.03	0.8611
	X3 X4	2.25	0.1642
	Lack of fit	1.15	0.4426	Not significant
R3, viscosity	Model	38.02	0.0001	Significant
	Linear mixture	60.81	<0.0001
	X1 X2	36.16	0.001
	X1 X3	2.67	0.1532
	X1 X4	9.75	0.0205
	X2 X3	3.04	0.1317
	X2 X4	61.22	0.0002
	X3 X4	2.94	0.1372
	Lack of fit	0.62	0.583	Not significant
R4, k-value	Model	5.75	0.0057	Significant
	Linear mixture	13.06	0.0009
	X1 X2	0.66	0.4349
	X1 X3	1.81	0.2082
	X1 X4	0.01	0.9421
	X2 X3	2.11	0.1771
	X2 X4	0.75	0.4066
	X3 X4	1.91	0.1968
	Lack of fit	1.66	0.2968	Not significant

Abbreviations: ANOVA, analysis of variance; PDI, polydispersity index.