Both EOC and EOC-CM injections significantly improve left ventricular chamber compliance in the SNX rat 4 weeks post-therapy initiation. 8 weeks after surgery, animals were subjected to invasive cardiac catheterization for cardiac functional analysis. The slope of the green line indicates the left ventricular end-diastolic pressure-volume relationship (LV EDPVR), an index of LV chamber compliance. (A–D): Representative pressure-volume loops. (A): Sham animal. (B): SNX-EBM-2 animal. (C): SNX-EOC-CM animal. (D): SNX-EOC animal. (E): Quantitative analysis of LV EDPVR. *, p < .05 versus sham-operated animals; †, p < .05 versus SNX-EBM-2 animals. Abbreviations: EBM-2, endothelial basal medium-2; EOC-CM, early outgrowth cell conditioned media; SNX, subtotal nephrectomy.