Figure 1. Pedigree showing the familial history of breast cancer. The disease history of the male breast cancer patient discussed in this study, denoted as Proband (arrow), showing the mother, sister, and daughter, who all died of breast cancer. The chromatograms show that the patients as well as all four surviving descendants are heterozygous for the BRIP1 mutation P919S. The surviving individuals' current ages are presented below the pedigree box (the “yr” denotes years), and the ages in parentheses indicate the age of death. The “nd” below the boxes denotes that the ages were not disclosed or available.