Table 4. Association of microRNA-222 expression levels with expression of epithelial-mesenchymal transition markers according to hormone receptor status.
| Marker | Hormone receptor-positive subgroup (n = 145) | Hormone receptor-negative subgroup (n=52) | ||||
|---|---|---|---|---|---|---|
| miR-222 low, No. (%) | miR-222 high, No. (%) | p-value* | miR-222 low, No. (%) | miR-222 high, No. (%) | p-value* | |
| Vimentin | 0.475 | 0.004 | ||||
| Negative | 63 (92.6) | 74 (96.1) | 11 (36.7) | 17 (77.3) | ||
| Positive | 5 (7.4) | 3 (3.9) | 19 (63.3) | 5 (22.7) | ||
| SMA | NA | 0.161 | ||||
| Negative | 68 (100) | 77 (100) | 22 (73.3) | 20 (90.9) | ||
| Positive | 0 | 0 | 8 (26.7) | 2 (9.1) | ||
| Osteonectin | 0.371 | 0.016 | ||||
| Negative | 67 (98.5) | 73 (94.8) | 20 (66.7) | 21 (95.5) | ||
| Positive | 1 (1.5) | 4 (5.2) | 10 (33.3) | 1 (4.5) | ||
| N-cadherin | 0.047 | 0.442 | ||||
| Negative | 66 (97.1) | 68 (88.3) | 24 (80/.0) | 20 (90.9) | ||
| Positive | 2 (2.9) | 9 (11.7) | 6 (20.0) | 2 (9.1) | ||
| E-cadherin loss | 0.036 | 0.075 | ||||
| Negative | 54 (80.6) | 50 (64.9) | 3 (10.0) | 7 (31.8) | ||
| Positive | 13 (19.4) | 27 (35.1) | 27 (90.0) | 15 (68.2) | ||
miR-222=microRNA-222; SMA=smooth muscle actin; NA=not available.
*p-values were calculated by the chi-square or Fisher exact test.