Table 3. Risk factors for cardiac event.
| Cardiac event | ||||||
|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | |||||
| OR | 95% CI | p-value | OR | 95% CI | p-value | |
| Age (yr) | - | - | - | |||
| < 55 | 1 | |||||
| ≥ 55 | 1.278 | 0.512–3.190 | 0.599 | |||
| Hypertension | ||||||
| No | 1 | 1 | ||||
| Yes | 1.984 | 0.738–5.334 | 0.175 | 2.498 | 0.852–7.329 | 0.095 |
| DM | - | - | - | |||
| No | 1 | |||||
| Yes | 1.693 | 0.567–5.057 | 0.346 | |||
| Overweight | - | - | - | |||
| No | 1 | |||||
| Yes | 0.459 | 0.129–1.641 | 0.231 | |||
| Hyperlipidemia | - | - | - | |||
| No | 1 | |||||
| Yes | 0.771 | 0.244–2.439 | 0.658 | |||
| Smoking | - | - | - | |||
| No | 1 | |||||
| Yes | 1.343 | 0.358–5.038 | 0.662 | |||
| Radiation | ||||||
| No | 1 | 1 | ||||
| Yes | 2.157 | 0.751–6.191 | 0.153 | 2.832 | 0.932–8.599 | 0.066 |
| Regimen | ||||||
| AC+T | 1 | 1 | ||||
| AC+T with docetaxel | 1.977 | 0.728–5.367 | 0.181 | 2.499 | 0.864–6.942 | 0.092 |
| Baseline LVEF | ||||||
| ≥ 60% | 1 | 1 | ||||
| < 60% | 2.337 | 0.815–6.704 | 0.114 | 2.075 | 0.691–6.235 | 0.193 |
| Dexrazoxane use | ||||||
| No | 1 | 1 | ||||
| Yes | 0.129 | 0.017–0.992 | 0.049 | 0.012 | 0.014–0.891 | 0.039 |
OR=odds ratio; CI=confidence interval; DM=diabetes mellitus; AC+T=doxorubicin with cyclophosphamide+trastuzumab; LVEF=left ventricular ejection fraction.