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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Alcohol Clin Exp Res. 2017 Feb 18;41(4):735–746. doi: 10.1111/acer.13343

Figure 3. Ethanol Inhibits Synaptic Vesicle Recycling During 40 Hz Stimulation of Medial BLA Inputs.

Figure 3

A–D) Cumulative amplitude plots of 40 Hz stimulation of stria terminalis inputs to the BLA at baseline and during exposure to 80mM ethanol. (A) Cells from AJ mice were sensitive to inhibition by ethanol during 40 Hz stimulation (t-test, p<0.05), (B) Cells from B6 mice were insensitive to ethanol during 40 Hz stimulation (t-test, p=0.72), (C) Cells from BALBc mice were sensitive to inhibition by 80mM ethanol during 40 Hz stimulation (t-test, p<0.01), (D) Cells from D2 mice were sensitive to inhibition by 80mM ethanol during 40 Hz stimulation (t-test, p<0.01). E–H) Quantification of ethanol effects on the size of the RRP and recycling pool (E) The recycling pool was significantly inhibited by ethanol in AJ mice (t-test, p<0.05) while the RRP was not (t-test, p=0.32), (F) The recycling pool was not altered by ethanol in B6 mice (t-test, p=0.85) and neither was the RRP (t-test, p=0.07), (G) The recycling pool was significantly inhibited in BALBc mice (t-test, p=0.006) while the RRP was not (t-test, p=0.20) (H) The recycling pool was significantly inhibited by ethanol in D2 mice (t-test, p=0.0002) while the RRP was not (t-test, p=0.06). I–L) Exemplar traces of 40 Hz stimulation of medial inputs (I) AJ, (J) B6, (K) BALBc, (L) D2.