Table 1.

Relative frequencies of oral adverse events compared with other countries in patients with hematologic malignancy

	Overholser CD	Williford SK	Raut A	Haytac MC	Akashi M	Shimada Y
Year	1982	1989	2001	2004	2013	2016
Nationality	USA	USA	USA	TUR	JPN	JPN
Total no. of pt.	28	26	388	124	37	160
No. of before chemotherapy pt.	–	5	2	0	0	75
Age (median)	–	–	–	7	50	63
Sex (m:f)	1:1.3	–	–	1.2:1	1.6:1	1.8:1
No. of tooth extraction pt.	28/28	26/26	69/388	48/124	10/37	28/75
Total no. of pt. with oral adverse event after chemotherapy	1/28 (3.6%)	7/26 (27%)	9/69 (13%)	10/48 (21%)	2/37 (5.4%)	9/75 (12%)
Total no. of pt. with systemic infection of oral origin	0/28 (0%)	0/26 (0%)	0/69 (0%)	0/48 (0%)	2/37 (5.4%)	0/75 (0%)
Delay of chemotherapy	0/28 (0%)	0/26 (0%)	4/69 (5.8%)	2/48 (4.2%)	0/37 (0%)	0/75 (0%)
SSI associated with tooth extraction	1/28 (3.6%)	1/26 (3.8%)	0/69 (0%)	0/48 (0%)	1/10 (10%)	1/28 (3.6%)