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. 2017 Apr 4;8:132. doi: 10.3389/fphar.2017.00132

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Copyright © 2017 Kumar, Barua, Sulakhiya and Sharma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histopathological changes were seen in mammary tumors after combined treatment of curcumin and cisplatin. (A) Breast cancer control group, (B) mammary tumor after treatment with curcumin: pronounced cell pleomorphism and a low grade of differentiation are demonstrated by multinucleated giant cells, (C) cisplatin treated mammary tumor with decreased cell density and higher level of fibrosis as sign of a therapeutic effect, (D) curcumin pre-treated mammary tumor after 5 days. The glandular structure as an indicator for a functional differentiation noticeable. (E) Quantitative analysis of histopathological studies in mammary tumor where, breast cancer control (A), curcumin treated mammary tumor (B), cisplatin-treated mammary tumor (C), and curcumin pretreated mammary tumor (D).