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. 2017 Apr 4;11:178. doi: 10.3389/fnins.2017.00178

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Copyright © 2017 Dideriksen, Laine, Dosen, Muceli, Rocon, Pons, Benito-Leon and Farina.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The level of tremor suppression obtained across the different trials for all patients using intramuscular (A) and surface (B) stimulation. The y-axis is truncated below –0.25. Several trials showed negative levels of tremor suppression below this point and are not shown in the plot. In both panels, each line indicates all trials from one patient (dashed line, Parkinson's Disease; unbroken line, Essential Tremor). The trials are ranked according to obtained suppression level (best trial first). Trials with statistical significant suppression are indicated with a symbol: Circles represent short stimulation duration (20% of tremor cycle), triangles represent long stimulation duration (40% of tremor cycle), and squares represents random stimulation timing. Symbol color indicates stimulation intensity: Gray represents stimulation at currents evoking high H-reflexes and black represents stimulation at currents evoking low H-reflexes.