Table 3. Functional genetic variants successfully identified at psychiatric risk locia.

Disease or phenotype	Locus	Functional variants	Target genes	Key methods	References
Schizophrenia, bipolar disorder	1p21.3	1:g.98515539A>T	MIR137/MIR2682	3C, EMSA, reporter assays	119
Schizophrenia, bipolar disorder	2q32.1	rs1344706	ZNF804A	eQTL, EMSA,	52, 136
Schizophrenia	2q32.1	rs359895	ZNF804A	EMSA, reporter assays	135
Bipolar disorder	7q21.11	rs13438494	PCLO	splicing assays	142
Bipolar disorder	7q21.1–q21.2	rs148754219	GRM3	eQTL, EMSA, reporter assays	137
Schizophrenia	10q24.32	VNTR	AS3MT	eQTL, reporter assays	51
Schizophrenia	11q23	rs1076560	DRD2	eQTL, splicing assays	141
Schizophrenia	12p13.3	rs2159100/rs12315711	CACNA1C	3C, reporter assays	120
Schizophrenia	12p13.3	rs1006737/rs4765905	CACNA1C	eQTL, 4C, reporter assays, protein arrays	124

Abbreviations: 3C, chromosome conformation capture; 4C, circular 3C; EMSA, electrophoretic mobility shift assay; eQTL, expression quantitative trait locus.

^aNonexhaustive list of examples. It should be noted that some of these genetic loci are positive only in candidate gene studies but not in genome-wide association studies (GWASs).