Figure 1.

Schematic representation of the known connections between Alzheimer's disease, Parkinson's disease, dementia with Lewy bodies and frontotemporal dementia. These disorders not only feature dementia as one of their core clinical manifestations but also share neuropathological alterations such as amyloid-β accumulation, Tau alterations (hyperphosphorylation or loss of function) and α-synuclein aggregation (Lewy bodies).