Table 2. GO analysis using the topGo tool for the genes with described epigenetic alterations in dementia.
| Ontology | GO terms | P-value | Genes |
|---|---|---|---|
| Biological process | Regulation of cellular component organization | 4.4e−09 | ABCA7, ANK1, BIN1, DNMT1, GRN, IGFBP7, MTHFR, PSEN1, SERPINF1, SERPINF2, SNCA, SORBS3, SORL1, SPTBN4, STX1B, TMEM59, TREM2 |
| Vesicle-mediated transport | 9.1e−08 | ABCA7, ANK1, APP, BIN1, C9orf72, GRN, PSEN1, SERPINF2, SNCA, SORL1, SPTBN4, STX1B, TREM2 | |
| Regulation of protein modification process | 2.4e−07 | ABCA7, APP, DNMT1, DUSP22, DUSP6, MTHFR, PSEN1, SERPINF2, SNCA, SORBS3, SORL1, SPTBN4, TMEM59, TREM2 | |
| β-Amyloid formation | 7.0e−07 | ABCA7, PSEN1, SORL1 | |
| Negative regulation of protein metabolic process | 8.2e−07 | ABCA7, APP, DNMT1, DUSP22, DUSP6, PSEN1, SERPINF1, SERPINF2, SNCA, SORL1, TMEM59 | |
| Negative regulation of proteolysis | 1.6e−06 | APP, PSEN1, SERPINF1, SERPINF2, SNCA, SORL1, TMEM59 | |
| Regulation of cellular protein metabolic process | 1.7e−06 | ABCA7, APP, DNMT1, DUSP22, DUSP6, MTHFR, PSEN1, SERPINF1, SERPINF2, SNCA, SORBS3, SORL1, SPTBN4, TMEM59, TREM2 | |
| Regulation of MAPK cascade | 3.5e−06 | ABCA7, DUSP22, DUSP6, PSEN1, SERPINF2, SORBS3, SORL1, SPTBN4, TREM2 | |
| Positive regulation of protein metabolic process | 3.6e−06 | ABCA7, APP, DNMT1, DUSP22, DUSP6, PSEN1, SERPINF2, SNCA, SORBS3, SORL1, SPTBN4, TREM2 | |
| Regulation of protein metabolic process | 4.1e−06 | ABCA7, APP, DNMT1, DUSP22, DUSP6, MTHFR, PSEN1, SERPINF1, SERPINF2, SNCA, SORBS3, SORL1, SPTBN4, TMEM59, TREM2 | |
| Molecular function | Endopeptidase inhibitor activity | 1.7e−04 | APP, SERPINF1, SERPINF2, SNCA |
| Tau protein binding | 1.8e−04 | BIN1, SNCA | |
| Endopeptidase regulator activity | 1.9e−04 | APP, SERPINF1, SERPINF2, SNCA | |
| Peptidase inhibitor activity | 2.0e−04 | APP, SERPINF1, SERPINF2, SNCA | |
| Enzyme binding | 2.7e−04 | ANK1, APP, BIN1, C9orf72, DNMT1, SERPINF2, SNCA, SORL1, SPTBN4, STX1B | |
| Peptidase regulator activity | 4.1e−04 | APP, SERPINF1, SERPINF2, SNCA | |
| Serine-type endopeptidase inhibitor activity | 5.2e−04 | APP, SERPINF1, SERPINF2 | |
| Structural constituent of cytoskeleton | 6.3e−04 | ANK1, SORBS3, SPTBN4 | |
| Spectrin binding | 7.9e−04 | ANK1, SPTBN4 | |
| Tyrosine/serine/threonine phosphatase activity | 2.7e−03 | DUSP22, DUSP6 |
Abbreviations: GO, gene ontology; MAPK, mitogen-activated protein kinase.
The top 10 more significant terms at the biological process and molecular function characterization levels are shown. P-values show the statistical significance of the enrichment of gene ontology terms with analyzed genes.