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. 2017 Apr 4;8:175. doi: 10.3389/fphar.2017.00175

FIGURE 2.

FIGURE 2

Ischemia-reperfusion-induced cardiac infarction was rescued by PLM treatment. Normal saline or PLM 10-8 g/kg was administered to rats 15 min before coronal artery ligation. Infarct volumes were determined after 1-h ischemia and 3-h reperfusion. Myocardial infarct size was assessed by Evans blue/2,3,5-triphenyltetrazolium chloride (TTC) double staining. Representative photographs of heart horizontal sections are shown (A). Blue-stained areas are non-ischemic regions; red-stained areas are ischemic-reperfused but viable regions; white areas are infarcted regions. Mean ± SEM of quantitative risk zone infarcted % (ratio of non-blue area to total area) (B), the infarct size/ AAR % (ratio of white area to non-blue area) (C), and plasma lactate dehydrogenase (LDH) activity (D) in age-matched control (n = 8), and PLM-treated rats (PLM, n = 8). ∗P < 0.05 represents a significant difference between control and PLM-treated groups. Values are expressed as mean ± SEM.