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. 2015 Jul 23;5:12464. doi: 10.1038/srep12464

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Copyright © 2015, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(A) Two major clusters were identified by unsupervised clustering analysis based on 334 expressed miRNAs in the serum of 70 NSCLC patients and 22 NC subjects. Samples are depicted in columns and microRNAs in rows. The histology of the samples (AC, adenocarcinoma; SCC, squamous cell carcinoma) is depicted in different colors at the top of the heat map. Overexpressed miRNAs are displayed in yellow whereas down-regulated microRNAs are displayed in blue. (B) Kaplan-Meier plot of overall survival and disease-free survival according to the cluster groups. Patient whose serum samples did not cluster with NC samples had significantly worse outcome.